Dating puma virus
Epstein-Barr virus (EBV) persistently infects greater than 90% of the population, and, in the vast majority of cases, the infection remains benign for life.
To establish a persistent latent infection, EBV must access the memory B cell compartment and reside within long-lived peripheral B cells  where few viral gene products are expressed in order to escape immune detection.
These findings, however, should not be extrapolated to other viral lineages without prior confirmation of virus-host co-divergence.
Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UKReceived 1 June 2011; Accepted 26 July 2011Academic Editor: Paola Andrea Chabay Copyright © 2011 Lindsay C. To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction.
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One way to circumvent this problem is to use changes accumulating in rapidly evolving genetic markers, such as associated pathogens, to infer the evolutionary history of the host.
This approach was recently used to investigate demographic and phylogeographic patterns in cougar populations (].